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0 mmHg with Mavacamten treatment
is a SHP-1 inhibitor
InChi: InChI=1S/C6H10N2O2/c1-6(2)4(9)7-5(10)8(6)3/h1-3H3
As a predictor for cardiotoxicity
NT157 007093 0 mmHg with Mavacamten treatmentIC50: 0. 3 to 0. 8 M NT157 is an IRS 1 2 inhibitor. Insulin receptor substrates 1 and 2 (IRS1 2) mediate antiapoptotic and mitogenic signaling from insulin receptor (IR), insulin like growth factor 1 receptor (IGF IR), and other oncoproteins. IRS1 plays a critical role in cancer cell proliferation, and its expression is increased in many human malignancies. In vitro: NT157 treatment was fonund to be able to lead to dose dependent suppression of IRS