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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
2(6):799-803
InChi: InChI=1S/C23H19N3O/c1-23(2
Smiles: CN(C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C(=O)C1=CC=CS1)C(C)=O
LDN-214117 - CAS# 1627503-67-6 60245 A selective USP1-UAF1 inhibitor linksLDN 214117, CAS No. 1627503 67 6, is a selective and potent ALK2 inhibitor. LDN 214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN 214117 shows a high degree of selectivity for ALK2 and low
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