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InChiKey: BJSDNVVWJYDOLK-UHFFFAOYSA-N
This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies
and severe agitation
Smiles: O=C(C1C=CC(=CC=1)NC1=NC(=CC=N1)C1=CC2=CC=CC=C2S1)N1CCC(CC1)N1CCCC1
SB-705498 - CAS# 501951-42-4 ine (hydrochloride monohydrate) InChiKey: BJSDNVVWJYDOLK-UHFFFAOYSA-NSB 705498 is an orally bioavailable, competitive antagonist of the capsaicin mediated activation of TRPV1 receptors (pKis = 7. 6, 7. 5, and 7. 3 for human, rat, and guinea pig, respectively). SB 705498 inhibits the capsaicin , acid , and heat mediated activation of the receptor. SB 705498 was shown to be a potent competitive antagonist of the capsaicin mediated activation of the human TRPV1 receptor (pK(i) = 7. 6) with activity at rat (pK(i) = 7. 5)
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