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MI-2 was used at 10-25 µM concentration in vitro and in the cellular assays
Smiles: CC1=NC=C(C=C1C1=CC(=C(N=C1)OC1CCOCC1)N1CCOCC1)NC(=O)C1=CC(=CC=C1)C(F)(F)F
RT112 cells) treatment decreases ERK1/2 phosphorylation
Pretreatment with 1 μM Sildenafil citrate potentiates the phosphorylation of ERK1/ERK2
ASTX-029 Size:10mg solid MI-2 was used at 10-25ASTX 029 is an orally bioavailable inhibitor of the extracellular signal regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX 029 inhibits ERK dependent tumor cell proliferation and survival. Product information CAS Number: 2095719 92 7 Molecular Weight: 584. 04 Formula: C29H31ClFN5O5 Chemical Name: (R) 2 (6 (5 chloro 2 ((tetrahydro 2H pyran 4 yl)amino)pyrimidin 4 yl) 1 oxoisoindolin 2 yl) N ((S) 1 (3 fluoro 5 methoxyphenyl) 2