E3 ligase Ligand 18 O-1211 CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C([O-])=O)C(=O)N2C=1C([O-])=O

CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C([O-])=O)C(=O)N2C=1C([O-])=O

Withaferin A (2 mg/kg

2012 Jan 17

171599-83-0

E3 ligase Ligand 18 O-1211 CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)CCC[C@@H](N)C([O-])=O)C(=O)N2C=1C([O-])=OE3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination mediated degradation of cancer promoting proteins. Product information CAS Number: 2241669 88 3 Molecular Weight: 436. 87 Formula: C17H17ClN6O4S Chemical Name: (2R) 3 ({2 amino 9 [(4 chlorophenyl)methyl] 6 oxo 6,9 dihydro 3H purin 8 yl}sulfanyl) 2 acetamidopropanoic