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The major caveats for the clinician to recognize are that HLA allele associations are currently known for a limited number of drugs, there is a wide range in quality of data supporting HLA allele associations, prevalence of at risk HLA alleles can vary greatly amongst different populations so may not be applicable to the providers patient/population, and the positive and negative predictive values (PPV and NPV) of having predisposing HLA alleles are highly variable

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As we look to the future of work, it's clear that flexibility and adaptability are key drivers of success, and casual dress codes are a step in the right direction