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InChiKey: YJDYDFNKCBANTM-QCWCSKBGSA-N
127(2):287-289
Smiles: N#CC1=C(C=CC2N=C(NC(=O)C3CC3)SC1=2)OC1=CC(NC(=O)CC2=CC(=CC=C2)C(F)(F)F)=C(F)C=C1
The affinity (Kd) for the dopamine D1 and D2 receptors during withdrawal from acute and chronic administration of reserpine is not change[1]
mTOR-IN-1 - CAS# 1207358-59-5 Catalog No.:M9817-2 InChiKey: YJDYDFNKCBANTM-QCWCSKBGSA-NmTOR IN 1 is a remarkably selective mTOR inhibitor with a Ki of 1. 5 nM. mTOR IN 1 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK) pharmacodynamic (PD) experiments. In Vitro: mTOR IN 1 (Compound 12i) inhibits mTOR with a Ki of 1. 5 nM, 500 fold selectivity over closely related PI3 kinases. mTOR IN 1 inhibits NCI PC3 and MCF7neo Her2 cells proliferation with IC50s of 150 nM and 57 nM, respectively[2]. In Vivo: mTOR IN 1
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