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ABT 888 dihydrochloride
tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain
5 to 25 μM sphingosine indicated a Ki of 9
InChiKey: AJRGHIGYPXNABY-UHFFFAOYSA-N
Y-39983 HCl - CAS# 173897-44-4 Catalog No.:M6858-10 ABT 888 dihydrochlorideY 39983 HCl, CAS No. 173897 44 4, also known as Y 33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3. 6nM for ROCK. Y 39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y 39983 downregulates RhoA Rho associated kinase expression during its promotion of axonal regeneration. Y 39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.
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