Sulindac sulfone Size:Contact [email protected] for quotation InChi: InChI=1S/C15H16O6S/c1-7-4-12(17)21-11-5-8(2-3-9(7)11)20-15-14(19)13(18)10(16)6-22-15/h2-5

InChi: InChI=1S/C15H16O6S/c1-7-4-12(17)21-11-5-8(2-3-9(7)11)20-15-14(19)13(18)10(16)6-22-15/h2-5

which is isolated from the aerial part of Consolida oliveriana

selective and irreversible inhibitor of factor XIa

InChi: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4

Sulindac sulfone Size:Contact [email protected] for quotation InChi: InChI=1S/C15H16O6S/c1-7-4-12(17)21-11-5-8(2-3-9(7)11)20-15-14(19)13(18)10(16)6-22-15/h2-5Sulindac sulfone is a metabolite of the nonsteroidal anti inflammatory drug (NSAID) sulindac. In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA 7 cells with an IC50 of 360 mmol L. Sulindac sulfone at 100 mmol L reduced 6 ketoPGF by 29. 2%. Sulindac sulfone reduced the colony number of HCA 7 and HCT 116 with an EC50 of 50 mmol l. Sulindac sulfone significantly decreased the expression of total cellular catenin (50% of control),