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FLI-06 was used at 10 µM final concentration in vitro and in cellular assays
and also owing to its anti-inflammatory effect
Endothelial cells treated with 1 microM 4-HPR fails to form tubes
Acadesine (500 μM) also causes a dramatic inactivation of HMG-CoA reductase
MSA 2 Catalog No.:M7585-10 FLI-06 was used at 10MSA 2 is a non nucleotide STING agonist. It exhibits antitumor activity and stimulates interferon secretion in tumors. MSA 2 induces tumor regression with durable antitumor immunity, and synergizes with anti PD 1 in syngeneic mouse tumor models. It is also orally bioavailable. Non nucleotide STING agonist (EC50 values are 8. 3 and 24 M for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon secretion
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