K-7174 Size:Solid 2 mg Iran J Basic Med Sci

Iran J Basic Med Sci

CAS Number: 55395-07-8

RPMI8226 cells) treatment induces caspase-dependent apoptosis in RPMI8226 cells in a dose-dependent manner

selective and cell-permeable class IIa HDAC inhibitor with IC50 of 126 nM

K-7174 Size:Solid 2 mg Iran J Basic Med SciK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product