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Epub 2010 May 17
LY-2090314
Maciejewski JP
187(9):4611-20
SR-59230A oxalate - CAS# 174689-39-5 Catalog No.:M7124-2 Epub 2010 May 17SR 59230A oxalate, CAS No. 174689 39 5, is a potent and selective 3 adrenoceptor antagonist (IC50 values are 40, 408 and 648 nM for 3, 1 and 2 receptors respectively). SR 59230A was subsequently shown to also act at 1 adrenoceptors at high doses. It has been shown to block the hyperthermia produced by MDMA in animal studies. SR 59230A blocks MDMA induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss
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