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(R)-CR8 trihydrochloride Size:10mg solid 3-bis(ylium)-4-uid-2-yl

SKU: 16667610840

4.6
USD155.00 USD205.00

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Description

3-bis(ylium)-4-uid-2-yl

11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17

InChi: InChI=1S/C42H63O4P/c1-37(2

5 to 25 μM sphingosine indicated a Ki of 9

(R)-CR8 trihydrochloride Size:10mg solid 3-bis(ylium)-4-uid-2-yl(R) CR8 (CR8) trihydrochloride, a second generation analog of Roscovitine, is a potent CDK1 2 5 7 9 inhibitor. (R) CR8 trihydrochloride inhibits CDK1 cyclin B (IC50=0. 09 M), CDK2 cyclin A (0. 072 M), CDK2 cyclin E (0. 041 M), CDK5 p25 (0. 11 M), CDK7 cyclin H (1. 1 M), CDK9 cyclin T (0. 18 M) and CK1 (0. 4 M). (R) CR8 trihydrochloride induces apoptosis and has neuroprotective effect. (R) CR8 trihydrochloride acts as a molecular glue degrader that

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