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NSC59984 specifically restores p53 pathway signaling in mutant p53-expressing human colorectal cancer cells
N-[4-[2-methoxyethyl(methyl)amino]phenyl]-2-phenyl-5-(trifluoromethyl)-1
Dapagliflozin Propanediol Monohydrate is a sodium-glucose cotransporter 2 (SGLT-2) inhibitor
Chemical Name: (2S)-2-amino-5-carbamimidamidopentanoic acid
BI-D1870 - CAS# 501437-28-1 Catalog No.:M11147-2 NSC59984 specifically restores p53 pathwayBI D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 1030 nM. BI D1870 exhibited a dose responsive antiproliferative effect on OSCC cells with relative sparing of normal human oral keratinocytes. The compound inhibited the downstream RSK target YB 1 and caused apoptosis. In addition, BI D1870 also induced G2 M arrest by modulating the expression of p21 and
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