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Y16 specifically inhibits LARG catalyzed activation of RhoA and RhoA signaling pathways
It is a weak inhibitor of PKA with an IC50 of 30 μM
InChi: InChI=1S/C9H9ClO4/c10-7-1-2-8(6(3-7)4-11)14-5-9(12)13/h1-3
(2015) Epigenomics
(S, R, S)-AHPC-Me ortmannin Y16 specifically inhibits LARG catalyzed(S, R, S) AHPC Me is the (S, R, S) AHPC based VHL ligand used in the recruitment of the von Hippel Lindau (VHL) protein. (S, R, S) AHPC Me can be used to synthesize ARV 771, a BET PROTAC degrader. Product information CAS Number: 1948273 02 6 Molecular Weight: 444. 59 Formula: C23H32N4O3S Synonym: VHL ligand 2 E3 ligase Ligand 1A Chemical Name: (2S, 4R) 1 [(2S) 2 amino 3, 3 dimethylbutanoyl] 4 hydroxy N [(1S) 1 [4 (4 methyl 1, 3 thiazol 5
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