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WAY-262611 2HCl
InChi: InChI=1S/C25H27ClN2
is a Positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells)
This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species
Raltitrexed - CAS# 112887-68-0 Size:Solid 2 mg WAY-262611 2HClRaltitrexed, also known as ZD 1694, is an antimetabolite drug used in treatment of colorectal cancer since 1998. It may also be used in the treatment of malignant mesothelioma. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Raltitrexed is a quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks