Romidepsin pitant metabolite N-desmethyl Netupitant 1007/s00280-016-3007-9

1007/s00280-016-3007-9

Binding was reversible

7 nM in rat cerebral cortical membranes

PluriSIn-1 was identified by a high-throughput screening against undifferentiated human ESCs

Romidepsin pitant metabolite N-desmethyl Netupitant 1007/s00280-016-3007-9Romidepsin, also known as FK228; is a bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia induced angiogenesis and depletes several heat shock