Siramesine Hydrochloride Catalog No.:M8962-10 7 µM) and inducing HIF-1α

7 µM) and inducing HIF-1α and HIF-2α expression in mice

Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats

1-dimethylurea

TAK-875 is currently in clinical trials for the treatment of type 2 diabetes mellitus

Siramesine Hydrochloride Catalog No.:M8962-10 7 µM) and inducing HIF-1αSiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 224177 60 0 Molecular Weight: 491. 04 Formula: C30H32ClFN2O Synonym: Lu 28 179 hydrochloride