SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid 9(12):2126-39

9(12):2126-39

4-Hydroxytamoxifen

PD153035 HCl (ZM 252868

Smiles: CCN1C=C(C2SC(=CC=2C1=O)C(=N)NC1CCS(=O)(=O)CC1)C1=CC(=CC=C1)C(F)(F)F

SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid 9(12):2126-39SAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low