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It shows more than 100-fold selectivity for mTOR relative to PI3Kα
550(7677):534-538
Smiles: CC1N=C(SC=1S(N)(=O)=O)N(C)C(=O)CC1=CC=C(C=C1)C1=CC=CC=N1
inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM
Bedaquiline Catalog No.:M8161-2 It shows more than 100-foldBedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.
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