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Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a
is a potent and selective inhibitor of protein arginine methyltransferases (PRMTs) PRMT 4 and PRMT6
being 14- and 24-fold less active compared with HER2
Harashima H
BMS-564929 0364 Sirtinol attenuates the proliferation andBMS 564929 is a highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator. BMS 564929 is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. Dose response studies in castrated male rats show that BMS 564929 is substantially more potent than testosterone (T) in stimulating the growth of the levator ani
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