ASK1-IN-2 losin Dihydroisotanshinone diminishes the ability of

Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner

COX-2-IN-2 shows good analgesic activity and no ulcerogenicity

Renaud A et al

Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins

ASK1-IN-2 losin Dihydroisotanshinone diminishes the ability ofASK1 IN 2 is a potent and orally active inhibitor of apoptosis signal regulating kinase 1 (ASK1), with an IC50 of 32. 8 nM. ASK1 IN 2 can be used for the research of ulcerative colitis. Product information CAS Number: 2541792 70 3 Molecular Weight: 364. 38 Formula: C19H17FN6O Chemical Name: 6 fluoro N {6 [4 (propan 2 yl) 4H 1,2,4 triazol 3 yl]pyridin 2 yl} 1H indole 2 carboxamide Smiles: CC(C)N1C=NN=C1C1=CC=CC(NC(=O)C2=CC3=CC=C(F)C=C3N2)=N1 InChiKey: