CB-6644 - CAS# 2316817-88-4 BI-98782 and exhibits no inhibition even

and exhibits no inhibition even at 1 mM for PHD2

selective and ATP-competitive Raf kinase inhibitor (IC50 = 10 nM)

aslo known as HA1100

This collection of signaling pathways is termed the ‘integrated stress response’ (ISR)

CB-6644 - CAS# 2316817-88-4 BI-98782 and exhibits no inhibition evenCB 6644 is a novel allosteric selective inhibitor of the ruvbl1 2 complex with anti cancer activity. CB 6644 blocks the ATPase activity of RUVBL1 2 with an IC50 of 15 nM. CB 6644 interacts specifically with RUVBL1 2 in cancer cells, leading to cell death. Importantly, drug acquired resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on target consequence of RUVBL1 2 engagement. In xenograft