CEP 1347 ITC Kowalik-Jankowska T

Kowalik-Jankowska T

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

irreversible inhibitor of the enzyme ornithine decarboxylase

InChi: InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6

CEP 1347 ITC Kowalik-Jankowska TCEP 1347, also called KT 7515, is an inhibitor of the c Jun N terminal kinase (JNK) signaling pathway, with an IC50 value for JNK1 activation of 20 2 nM in rat embryonic motoneurons . The JNK pathway, also known as the stress activated protein kinase (SAPK) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. JNK activation by phosphorylation is important for neuronal cell death