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2018:4904696
inhibiting cell growth by 50–100% at 10 μM in 40 of 48 cell lines tested
1 µM in the Rheb-IVK assay
CC(C)CN1C=NC2=C(N)N=C3C=CC=CC3=C12
DVD-445 nib mesylate 2018:4904696DVD 445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0. 60 M for rat TrxR1. DVD 445 has good anticancer application. Product information CAS Number: 2375846 41 4 Molecular Weight: 458. 50 Formula: C25H28F2N2O4 Chemical Name: 2 {[(tert butylcarbamoyl)(4 fluorophenyl)methyl](methyl)amino}ethyl (2E) 4 (4 fluorophenyl) 4 oxobut 2 enoate Smiles: CN(CCOC(=O) C=C