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[Epub ahead of print] PubMed PMID: 30511343
Formula: C9H8N2OS2
4(12):e8104
Formula: C14H18ClN3O2S
APS-2-79 - CAS# 2002381-25-9 size:2mg solid [Epub ahead of print] PubMedAPS 2 79, CAS No. 2002381 25 9, is a KSR dependent MAPK modulator. APS 2 79 modulates KSR dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR bound MEK (mitogen activated protein kinase kinase). APS 2 79 increased the potency of several MEK inhibitors specifically within Ras mutant cell lines by antagonizing release of negative feedback signalling,
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