Tubulysin D Catalog No.:M25933-C Smiles: COC(=O)C[C@H](NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)OCC1C=CC=CC=1)C(=O)CF

Smiles: COC(=O)C[C@H](NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)OCC1C=CC=CC=1)C(=O)CF

Smiles: CN1CCN(CC1)C1C=C2NC(=NC2=CC=1)C1=CC(=C(OCCCC(=O)NCCCN=[N+]=[N-])C(=C1)C(C)(C)C)C(C)(C)C

with IC50s of 29 and 803 nM for JAK1 and JAK2

In a cholera model

Tubulysin D Catalog No.:M25933-C Smiles: COC(=O)C[C@H](NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)OCC1C=CC=CC=1)C(=O)CFTubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1. 7 M. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug resistant cell