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RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon
InChi: InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5
3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1
21(9):pii: E1145
Cafestol - CAS# 469-83-0 exofenadine D6 RO8191 shows antiviral activity againstCafestol, one of the major components of coffee, is a coffee specific diterpene from. Cafestol is a ERK inhibitor for AP 1 targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX) 2 in LPS activated RAW264. 7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as