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transformation
Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor
Smiles: CC(=O)C1C=CC(=CC=1)NC(=O)C=CC1=CC=C(CC)O1
Crenolanib (1 nM-10 μM) stimulates ABCB1 ATPase activity in a concentration-dependent manner
PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid transformationPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.
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