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Smiles: C/C(=C\C(O)=O)/C=C/C=C(\C)/C=C/C1=C(C)C(C)=C(C=C1C)OC
Smoothened Antagonists Reverse Taxane Resistance in Ovarian Cancer
Formula: C17H18N6
19(3):297-312
PP2 - CAS# 172889-27-9 Catalog No.:M9704-10 Smiles: C/C(=C\C(O)=O)/C=C/C=C(\C)/C=C/C1=C(C)C(C)=C(C=C1C)OCPP2, also known as AG 1879, is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP 70 (100 M) and JAK2 (50 M). Despite its extensive use as a Src selective inhibitor, recent research has shown that PP2 is non selective and inhibits many
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