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with a Ki of 2 nM
Gossypetin (20-60 μM
a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform
In NCI-H345 cells possessing CCKB/gastrin receptors
Z-DQMD-FMK 17517 with a Ki of 2Inhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and
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