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Smiles: CNC1=CC=C(/C=C/C2=CN=C(C=C2)OCCOCCOCCF)C=C1
MAPK and Akt pathways
+2/p-2/t2*26-
24 hours) promotes the percentage of apoptotic cells in a dose-dependent manner
TAK-683 acetate 27620 Smiles: CNC1=CC=C(/C=C/C2=CN=C(C=C2)OCCOCCOCCF)C=C1TAK 683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK 683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0. 96 nM and 1. 6 nM for human and rat, respectively. TAK 683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone dependent prostate