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SB-743921 (1
is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431
highly potent and selective non-ATP competitive MEK inhibitor
SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein
TW-37 Catalog No.:M7872-2 SB-743921 (1TW 37 is a small molecule inhibitor of Bcl 2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. TW 37 induces cell growth inhibition and S phase cell cycle arrest, with regulation of several important cell cycle related genes like p27, p57, E2F 1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch 1, Jagged 1, and its