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Nutlin-3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein
InChi: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H
4-dihydro-2H-chromen-4-yl]amino}imidazo[1
The IC50 for inhibition of MEK1 by CI-1040 is 0
AICAR phosphate Size:Solid 10 mg Nutlin-3 activates the p53 pathwayAICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor. Product information CAS Number: 681006 28 0 Molecular Weight: 356. 23 Formula: C9H17N4O9P Chemical Name: 5 amino 1 [3,4 dihydroxy 5 (hydroxymethyl)oxolan 2 yl] 1H imidazole 4