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selective inhibitor of the TGF-β type I receptor ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation
Favipiravir does not inhibit RNA or DNA synthesis in mammalian cells and is not toxic to them
Epub 2015 Jun 1
is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2)
ROC-325 - CAS# 1859141-26-6 size:2mg solid selective inhibitor of the TGF-βROC 325, CAS No. 1859141 26 6, is an autophagy inhibitor. ROC 325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC 325 antagonized RCC growth and survival in an ATG5 7 dependent manner, induced apoptosis, and exhibited favorable selectivity. Product information CAS Number: 1859141 26 6 Molecular Weight: 503. 06