ONO-4059 (analog) or modulator-1 Su-11274 suppresses proliferation and motility

Su-11274 suppresses proliferation and motility of pancreatic cancer cells

Formula: C17H19NO3

and 1127 nM for p110α

Formula: C18H19N3O2S

ONO-4059 (analog) or modulator-1 Su-11274 suppresses proliferation and motilityONO 4059 analog is the analog of ONO 4059, ONO 4059 is a highly potent and selective Btk inhibitor. IC50 value: sub nM range Target: Btkin vitro: ONO 4059 is a selective, once daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B cells. ONO 4059 shows a favourable safety profile along with promising efficacy in this difficult to treat patient population. in vivo: ONO 4059 has demonstrated