Danoprevir 2-yl)ethane-1 2-diamine hydrochloride is a highly potent and

is a highly potent and selective inhibitor of the MLL1/WDR5 interaction with an IC50 ~2

a protein that guards and repairs the neuronal genome

900305-37-5

SKL2001 is an agonist of the Wnt/β-catenin pathway

Danoprevir 2-yl)ethane-1 2-diamine hydrochloride is a highly potent andDanoprevir, also known as ITMN 191 and RG 7227, is under development by InterMune Inc and Roche Holding AG, is a promising, potent NS3 4A protease inhibitor for the oral treatment of HCV infection. Preclinical data demonstrated that danoprevir binds with high affinity and dissociates slowly from the HCV NS3 protease, allowing high liver drug exposure with only modest plasma drug exposure. A phase Ib, 'IFN free' clinical trial demonstrated that