RKI-1447 - CAS# 1342278-01-6 Catalog No.:M60415-2S and induces caspase-dependent apoptosis in

and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells

VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification

and anchorage-independent colony formation in soft agar

and MDA-MB436 ER negative breast cancer cells

RKI-1447 - CAS# 1342278-01-6 Catalog No.:M60415-2S and induces caspase-dependent apoptosis inRKI 1447, CAS No. 1342278 01 6, is a potent inhibitor of the Rho associated ROCK kinases with anti invasive and antitumor activities in breast cancer. RKI 1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI 1447 suppressed phosphorylation of the ROCK substrates MLC 2 and MYPT 1 in human cancer cells. Product information CAS Number: 1342278 01 6 Molecular Weight: 326. 37