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3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2
2009 Jul 23
Formula: C4H11N3O3
CAS Number: 173904-50-2
GX-674 2592 3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2GX 674 is an aryl sulfonamide class of antagonists that inhibits Nav1. 7 Nav (voltage gated sodium) channels conduct ionic currents that initiate action potentials in neurons and muscles cells. Human express 9 Nav channel isoforms (Nav 1. 1 1. 9), among which Nav 1. 7 channel are express in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. Gain of function mutations in Nav1. 7 are associated with extreme pain
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