ML-290 0191584 maleate Smiles: CC1NC(=O)C2=CC(CN(CC#C)C3C=CC(=CC=3)C(=O)NCC3=CN=CC=C3)=C(Br)C=C2N=1

Smiles: CC1NC(=O)C2=CC(CN(CC#C)C3C=CC(=CC=3)C(=O)NCC3=CN=CC=C3)=C(Br)C=C2N=1

which is potent and selective against BaF3-tel-c-KIT (IC50 of 4 nM) and a broad spectrum of drug-resistant mutants (IC50 of 8 nM for BaF3-tel-c-KIT-T670I) with improved bioavailability

Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment

InChiKey: HXAJCOUXPGZOSR-AILNWJDNSA-N

ML-290 0191584 maleate Smiles: CC1NC(=O)C2=CC(CN(CC#C)C3C=CC(=CC=3)C(=O)NCC3=CN=CC=C3)=C(Br)C=C2N=1ML 290 is a first in class and potent relaxin insulin like family peptide receptor (RXFP1) agonist and activator of anti fibrotic genes, with an EC50 of 94 nM. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Product information CAS Number: 1482500 76 4 Molecular Weight: 506. 49 Formula: C24H21F3N2O5S Chemical Name: 2 (propan 2 yloxy) N {2 [(3 trifluoromethanesulfonylphenyl)carbamoyl]phenyl}benzamide Smiles: