GSK J5 tan (medoxomil monopotassium) 4 - d] pyrimidin -3

4 - d] pyrimidin -3 - one analogs

InChiKey: KJNNWYBAOPXVJY-UHFFFAOYSA-N

BRD4(BD2) and BRD4(BD1BD2)

InChiKey: KGFCORDWMRCVAC-VYIZRSQBSA-N

GSK J5 tan (medoxomil monopotassium) 4 - d] pyrimidin -3The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.,. GSK J4 is a cell permeable prodrug which is modified by intracellular esterases to give GSK J1, an inhibitor of JMJD3. GSK J5 is a pyridine regio isomer of GSK J4. Like GSK J4, this isomer is cell permeable and hydrolyzed to a free base. 3 However, the free base is a