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pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs
or in combination with Docetaxel (15 mg/kg) or Irinotecan (25 mg/kg) to significantly reduce the tumor volume
NMS-873 activated the unfolded protein response
but TSC1+/+ cells are resistant
CAY10603 - HDAC6 Inhibitor. CAS# 1045792-66-2 60169 pan FGFR kinase inhibitor BGJ398CAY10603, CAS No. 1045792 66 2, is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0. 42 nM, 6851 nM, and 90. 7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 M. It could be useful chemical probe to study HDAC biology. Product information CAS Number: 1045792 66 2 Molecular Weight: 446. 50 Formula: C22H30N4O6 Chemical Name:
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