CFI-400437 HCl - inhibitor of polo-like kinase 4 (PLK4). CAS# 1247000-76-5 hyronine Smiles: C/C(=N\NC(=O)C1=CC(=CC=C1)S(=O)(=O)N1CCOCC1)/C1=CC(Cl)=CC=C1O

Smiles: C/C(=N\NC(=O)C1=CC(=CC=C1)S(=O)(=O)N1CCOCC1)/C1=CC(Cl)=CC=C1O

3-triazol-4-yl}methyl)amino]-8-chloro-4-[(3-chloro-4-fluorophenyl)amino]quinoline-3-carbonitrile

InChiKey: SVUJNSGGPUCLQZ-FQQAACOVSA-N

808 nM (Human PKCε) Ki: 5

CFI-400437 HCl - inhibitor of polo-like kinase 4 (PLK4). CAS# 1247000-76-5 hyronine Smiles: C/C(=N\NC(=O)C1=CC(=CC=C1)S(=O)(=O)N1CCOCC1)/C1=CC(Cl)=CC=C1OCFI 400437 is a potent and selective inhibitor of polo like kinase 4 (PLK4). The family of Polo like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4. Product information CAS Number: 1247000 76 5 Molecular Weight: 565. 49 Formula: C29H30Cl2N6O2