W-54011 Catalog No.:M20237-C Smiles: NC(=O)C1C=CC(=CC=1)C1C=NN2C=CC(NCC3=CN=CC=C3)=NC2=1

Smiles: NC(=O)C1C=CC(=CC=1)C1C=NN2C=CC(NCC3=CN=CC=C3)=NC2=1

Smiles: C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]1C[C@@](O)(CC2C1=C(O)C1C(=O)C3=C(C=CC=C3C(=O)C=1C=2O)OC)/C(/CO)=N/NC(=O)CCCCCN1C(=O)C=CC1=O

87(1):83-7

Jacobine is a pyrrolizidine alkaloid (PA) from Senecio jacobaea

W-54011 Catalog No.:M20237-C Smiles: NC(=O)C1C=CC(=CC=1)C1C=NN2C=CC(NCC3=CN=CC=C3)=NC2=1W 54011 is a potent and orally active non peptide C5a receptor antagonist. W 54011 inhibits the binding of 125I labeled C5a to human neutrophils with a Ki value of 2. 2 nM. W 54011 also inhibits C5a induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3. 1 nM, 2. 7 nM, and 1. 6 nM, respectively. Product information CAS Number: 405098 33 1 Molecular Weight: 493. 08 Formula: C30H37ClN2O2 Chemical