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Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis
Formula: C17H19ClFN7O
InChiKey: ZNSVOHSYDRPBGI-CBQRAPNFSA-N
Smiles: CCNC(=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2C=CC=CC=2)[C@H](O)C[C@@H]1O
CpdA Size:Contact [email protected] for quotation Transfection of Poly (I:C) intoCpdA is a non steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus. It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF B and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone that were either higher (4 fold, IC50 =
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