CRT 0066101 15726 Aclacinomycin A shows cytotoxic activity

Aclacinomycin A shows cytotoxic activity with IC50 values of 0

Smiles: CS(=O)(=O)NC1C=CC(=CC=1)OCCN(C)CCC1C=CC(=CC=1)NS(C)(=O)=O

Lersivirine is able to inhibit HIV-1 virus replication in MT-2 cells infected with wt NL4-3

2*2-1-/t24-

CRT 0066101 15726 Aclacinomycin A shows cytotoxic activityIC50: A potent protein kinase D (PKD) antagonist with the IC50 of 1, 2. 5 and 2 nM for PKD1, PKD2, PKD3 respectively. CRT 0066101 is a specific inhibitor of all PKD isoforms. Increasingly studies reveals that PKD family members play an important role in regulating several cellular processes and activities, including chromatin organization, Golgi function, gene expression, cell survival, adhesion, motility, differentiation, DNA synthesis and