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a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases
InChi: InChI=1S/C21H15ClF4N4O3
Chemical Name: 3-((6-(4
Its main effects are dilation of the arteries supplying blood to the legs and decreasing platelet coagulation
RAF265 enafil dihydrochloride a potent and selective CRTh2CHIR 265 is an orally bioavailable small molecule with potential antineoplastic activity. CHIR 265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR 2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras Raf MEK ERK signaling pathway and are frequently
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