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Diverse chemical scaffolds support direct inhibition of the membrane bound O-acyltransferase Porcupine
It is selective for HECT-mediated over RING-mediated ubiquitination
Smiles: CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC=CC=3)=NC=2C=C1
(2008) Leukemia
GO-6976 - CAS# 136194-77-9 10001 Diverse chemical scaffolds support directGO 6976, CAS No. 136194 77 9, also known as PD 406976, is a potent inhibitor of neurotrophin receptor intrinsic tyrosine kinase. GO 6976 blocked neurotrophin induced signaling and autophosphorylation of neurotrophin specific tyrosine kinase (Trk) receptors, either Trk B in cortical neurons or Trk A in GT1 1 trk9 cells. Product information CAS Number: 136194 77 9 Molecular Weight: 378. 43 Formula: C24H18N4O Synonym: PD406976 Chemical Name: 3 (13 methyl
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