LW 6 - CAS# 934593-90-5 0185 Smiles: C1NC[C@H]2C[C@@H]1C1=CC3=NC=CN=C3C=C12

Smiles: C1NC[C@H]2C[C@@H]1C1=CC3=NC=CN=C3C=C12

and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells

18(11):1401-12

In H4 cells expressing the mCherry-GFP-LC3 reporter PIK-III inhibits the formation of mCherry-positive autolysosomes and increases the cytosolic signal of LC3 under basal conditions and when autophagy is induced with the mTOR inhibitor AZD8055

LW 6 - CAS# 934593-90-5 0185 Smiles: C1NC[C@H]2C[C@@H]1C1=CC3=NC=CN=C3C=C12LW 6, CAS No. 934593 90 5, was first identified and reported by a group scientists from Korea. LW8 was found to inhibits the accumulation of HIF 1alpha. LW6 decreased HIF 1alpha protein expression without affecting HIF 1beta expression. It was further found that LW8 promoted the degradation of wild type HIF 1alpha, but not of a DM HIF 1alpha with modifications of P402A and P564A, at hydroxylation sites in the oxygen dependent degradation domain