LY-411575 (isomer 3) nserin Ishikawa J

Ishikawa J

InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

InChi: InChI=1S/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17

The combination of tamoxifen and R115777 results in significantly lower Ki-67 compared with either tamoxifen or R115777 alone (mean of 5% versus 16

LY-411575 (isomer 3) nserin Ishikawa JLY 411575 isomer 3, is an isomer of LY411575, which is a potent, cell permeable secretase inhibitor (IC50= 0. 078 nM 0. 082 nM (in membrane assay in cell based secretase assays)) and also inhibits Notch clevage (IC50= 0. 41 nM). Product information CAS Number: 2070009 28 6 Molecular Weight: 479. 48 Formula: C26H23F2N3O4 Synonym: LY411575 isomer 3 LY 411575 isomer 3 Chemical Name: (2R) 2 [(2R) 2 (3, 5 difluorophenyl) 2 hydroxyacetamido] N [(10S) 8